A study published in the New England Journal of Medicine has evaluated the effect of pre-emptive infusion of omeprazole before endoscopy on the need for endoscopic therapy.
Over a 17-month period, consecutive patients admitted with upper GI bleeding were stabilised and then randomised to omeprazole 80-mg IV bolus followed by 8mg/hour infusion (n= 319) or matching placebo (n= 319) before endoscopy the next morning.
The following findings were reported:
The study concluded “infusion of high-dose omeprazole before endoscopy accelerated the resolution of signs of bleeding in ulcers and reduced the need for endoscopic therapy.”
N Engl J Med 2007; 356: 1631-40 (link to abstract)